Excitement is building here at CEA for attending EUROTOX in Copenhagen next week! One of the hot topics that we will be following closely is dose-response in the context of genotoxicity.
Genotoxicity is a key regulatory endpoint that was developed originally as a proxy for cancer, or an “easy way” to detect carcinogens. We now know that things are not that simple (they seldom are), and we draw distinction between genotoxic / nongenotoxic carcinogens, and recognise sub-endpoints such as mutagenicity, clastogenicity, aneugenicity, chromosome damage and DNA damage. As a result, genotoxicity evaluation has become a useful tool in every toxicologist’s toolbox for prioritising and screening chemicals. Its refinement is becoming increasingly important, as chemical regulations call for ever-more-subtle evaluation, and our continually improving analytical capabilities expose an ever-more-complex environmental mix.
How can we effectively use dose-response and mechanistic data when evaluating the genotoxic endpoint? Can genotoxicity be used for quantitative risk assessment? If so, how? These are only some of the many questions we will be thinking about next week …
If you will be attending EUROTOX 2024, please come and meet Emma, Georgia and Bashir at the CEA booth (We are at Booth Number #50!). We would be delighted to discuss this or any other toxicology topic, and the services we can offer to your organisation.