Toxicology, ecotoxicology and risk assessments

CEA provides tailored solutions for all human safety evaluation needs. Our team’s expertise and significant experience can also provide you with fully integrated ecotoxicology and toxicology risk assessments. We offer support for hazard, exposure and risk assessment for general chemicals, agrochemicals, biocides, veterinary and human medicines, food and food additives and cosmetics and our capabilities include

  • collating, evaluating and interpretating data
  • evaluating endocrine disruptors
  • analysing data gaps
  • deriving acceptable exposure levels/reference doses
  • using alternative approaches e.g., in silico and in vitro investigations
  • assessing (Q)SAR
  • developing strategies and approaches to minimise/avoid testing, including exposure-based waiving and read-across
  • advising on complex study designs and programmes
  • managing timely and value-conscious testing programmes
  • preparing robust summaries in IUCLID, chemical safety reports (CSR) and cosmetic product safety reports.

Ecotoxicology

CEA provides a full range of ecotoxicology services, including

  • identifying studies needed for regulatory compliance
  • reviewing literature and data searches on specific substances
  • placing investigations at selected CROs and monitoring studies to ensure they are compliant
  • preparing study summaries, Klimisch evaluations and entering data into IUCLID
  • preparing study protocols for non-standard ecotoxicology studies and obtaining regulatory approval for the non-standard studies
  • calculating PNECs from the study endpoints and assigning assessment factors
  • preparing read-across justifications for REACH registration dossiers
  • evaluating endocrine disruptor properties.

Risk assessment

CEA is highly skilled in evaluating the risk of general chemicals to the environment and human health, under REACH. CEA provides expertise reviewing product uses, building exposure scenarios and assessing risks using regulatory accepted models (e.g., ECETOC TRA, CHESAR, ConsExpo). Our experts specialise in higher-tier risk assessments and work closely across ecotoxicology, toxicology and environmental fate to develop realistic exposure assessments.

Meet the team